ACCELERATED CD8+ T-CELL MEMORY AFTER DENDRITIC CELL VACCINATION

摘要

Disclosed are compositions and methods for Here, it is shown that vaccination with peptide-coated dendritic cells (DC) generated antigen-(Ag) specific CD8⁺ T-cells with the phenotype and function of memory T-cells as early as 4-6 days after immunization. These memory-like CD8⁺ T-cells underwent vigorous secondary expansion, resulting in rapid generation of elevated secondary memory CD8⁺ T-cell numbers and increased protective immunity, in response to a variety of booster immunizations. However, concurrent inflammation prevented the rapid generation of memory T-cells by DC immunization. Thus, DC vaccination, in the absence of overt inflammation, accelerated memory cell generation and dramatically reduced the interval required for booster amplification of memory CD8⁺ T-cell numbers.