TUBERCULOSIS VACCINES COMPRISING ANTIGENS EXPRESSED DURING THE LATENT INFECTION PHASE

摘要

The invention is related to an immunogenic composition, vaccine or
pharmaceutical
composition for preventing, boosting or treating infection caused by a species
of the
tuberculosis complex (M tuberculosis, M. bovis, M. africanum, M. microti).
The
immunogenic composition, vaccine or pharmaceutical composition comprise a
fusion
polypeptide, which comprises one or more starvation antigens from M.
tuberculosis, the units
of the fusion polypeptide being M. tuberculosis antigens. Further, the
invention is related to
the use of a vaccine comprising a fusion polypeptide sequence or nucleic acid
sequence of the
invention given at the same time as BCG, either mixed with BCG or administered
separately
at different sites or routes for preparing said immunogenic composition,
vaccine, or
pharmaceutical composition.