发明名称 |
P21 derived peptides and uses thereof |
摘要 |
The present invention relates to p21 derived peptides capable of inhibiting CDK/cyclin complexes, particularly cyclins A or E/CDK2, by modifying the interaction with their substrates. The peptides are derived from a C-terminal region of p21 and display selectivity for cyclin/CDK2 inhibition over cyclin/CDK4 inhibition. Variants of such peptides particularly involving certain alanine replacements are shown to be particularly potent.
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申请公布号 |
US2006293245(A1) |
申请公布日期 |
2006.12.28 |
申请号 |
US20060407880 |
申请日期 |
2006.04.20 |
申请人 |
CYCLACEL LIMITED |
发明人 |
ZHELEVA DANIELLA I.;FISCHER PETER M.;MCINNES CAMPBELL;ANDREWS MARTIN J.;CHAN WENG C.;ATKINSON GAIL E. |
分类号 |
C07K7/06;A61K38/00;A61K38/08;G01N33/573;G01N33/574 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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