发明名称 |
Novel bichalcophenes and their prodrugs as antiprotozoal agents |
摘要 |
Novel dicationic bichalcophene compounds are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium falciparum, or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic bichalcophene compounds displayed good activity in vivo in a murine model of a Trypanosoma brucei rhodesiense infection.
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申请公布号 |
US2006293540(A1) |
申请公布日期 |
2006.12.28 |
申请号 |
US20060435323 |
申请日期 |
2006.05.16 |
申请人 |
TIDWELL RICHARD R;BOYKIN DAVID W;STEPHENS CHAD;ISMAIL MOHAMED A;WILSON W D;BRUN RETO;WERBOVETZ KARL |
发明人 |
TIDWELL RICHARD R.;BOYKIN DAVID W.;STEPHENS CHAD;ISMAIL MOHAMED A.;WILSON W. D.;BRUN RETO;WERBOVETZ KARL |
分类号 |
C07C211/00 |
主分类号 |
C07C211/00 |
代理机构 |
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