发明名称 |
PROCESS FOR THE PREPARATIVE PURIFICATION OF VIRUS-LIKE PARTICLES (VLPS) |
摘要 |
The invention provides a process for the purification recombinantly expressed, self- assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography using hydroxyapatite and, optionally, a size exclusion chromatography. VLP preparations obtained by the process of the invention are essentially free of endotoxin contaminations. |
申请公布号 |
WO2006136566(A1) |
申请公布日期 |
2006.12.28 |
申请号 |
WO2006EP63373 |
申请日期 |
2006.06.20 |
申请人 |
CYTOS BIOTECHNOLOGY AG;RICHTER, SUSANNE;TOPELL, SIMON |
发明人 |
RICHTER, SUSANNE;TOPELL, SIMON |
分类号 |
C12N7/02;C12N7/04 |
主分类号 |
C12N7/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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