发明名称 |
SYNTHESIS OF SALINOSPORAMIDE A AND ANALOGUES THEREOF |
摘要 |
A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.
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申请公布号 |
WO2006124902(A3) |
申请公布日期 |
2006.12.28 |
申请号 |
WO2006US18924 |
申请日期 |
2006.05.16 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH;DANISHEFSKY, SAMUEL;ENDO, ATSUSHI |
发明人 |
DANISHEFSKY, SAMUEL;ENDO, ATSUSHI |
分类号 |
A61K31/397;A61K31/4015;A61K31/407;C07D209/52 |
主分类号 |
A61K31/397 |
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