METAL-ENHANCED FLUORESCENCE-BASED SENSING METHODS

摘要

The present invention relates to metallic-surface detection systems for d etermining target substances including free bilirubin in neonatal serum in t he presence of a predominantly high background of bilirubin bound Human Seru m Albumin (HSA) or sensing and isolating target nucleotide sequences wherein a fluorescence signal is enhanced by close proximity of the target substanc es near metallic surfaces.