SYNERGISTIC MODULATION OF FLT3 KINASE USING A FLT3 INHIBITOR AND A FARNESYL TRANSFERASE INHIBITOR
摘要
<p>The invention is directed to a method of inhibiting FLT3 tyrosine kinase activity or expression or reducing FLT3 kinase activity or expression in a cell or a subject comprising the administration of a farnesyl transferase inhibitor and a FLT3 kinase inhibitor selected from compounds of Formula (I'). Included within the present invention is both prophylactic and therapeutic methods for treating a subject at risk of (or susceptible to) developing a cell proliferative disorder or a disorder related to FLT3.</p>
申请公布号
WO2006138155(A1)
申请公布日期
2006.12.28
申请号
WO2006US22412
申请日期
2006.06.07
申请人
JANSSEN PHARMACEUTICA N.V.;BAUMANN, CHRISTIAN, ANDREW;GAUL, MICHAEL DAVID;TUMAN, ROBERT, W.;JOHNSON, DANA, L.
发明人
BAUMANN, CHRISTIAN, ANDREW;GAUL, MICHAEL DAVID;TUMAN, ROBERT, W.;JOHNSON, DANA, L.