IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES

摘要

The invention provides a compound of formula (I); or a salt or solvate thereof, wherein: R<SUP>1</SUP> is hydrogen or C<SUB>1-4</SUB>alkyl; R<SUP>2</SUP> and R<SUP>4</SUP> are each independently selected from C<SUB>1-4</SUB> alkyl, [<SUP>11</SUP>C] C<SUB>1 4</SUB>alkyl, and [<SUP>18</SUP>F]-C<SUB>1-4</SUB> fluoroalkyl provided that at least one of R<SUP>2</SUP> and R<SUP>4</SUP> is [<SUP>11</SUP>C] C<SUB>1 4</SUB>alkyl or [<SUP>18</SUP>F]-C<SUB>1-4</SUB> fluoroalkyl; and R<SUP>3</SUP> is halo. Such compounds having use for imaging central nervous system receptors.