ANALYTE DETECTION DEVICES AND METHODS WITH HEMATOCRIT/VOLUME CORRECTION AND FEEDBACK CONTROL

摘要

An arrangement (10) for measuring the concentration of an analyte contained in a sample of body fluid includes: an assay pad (40) comprising at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot (50) formed upon reaction with the analyte; a light source (32); a detector array (20); a processor (84); and a memory (80) in communication with the processor. The memory (80) includes at least one value indicative of one or more of: (i) the level of hematocrit contained in the sample; (ii) the volume of the sample applied to the assay pad; or (iii) imperfections present in the reaction spot; and further including at least one algorithm for calculating the concentration of the analyte contained in the sample. Alternatively, an arrangement (10) is described for measuring the concentration of an analyte contained in a sample of body fluid, the arrangement including: an assay pad (40) comprising at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot (50) formed upon reaction with the analyte; a light source(32); a detector array (20); a processor (84); a memory (80) in communication with the processor; and at least one catalyst device constructed and arranged to be responsive to control signals.