发明名称 |
Salicylate therapeutic compound and process for controlled delivery thereof |
摘要 |
A therapeutic composition includes a salicylate administering concert with at least one salicylate excretion compound of a glycine salicylate conjugate and a gluconoride salicylate conjugate. A therapeutic composition is provided that has an extended excretion half-life for a salicylate that includes the administration of the salicylate in concert with an enzymatic substrate competitor. The enzymatic substrate competitor being competitive with salicylate or gluconoride. Salicylate enzymatic substrate competitors include benzoate or other aromatic derivatives, while gluconoride enzymatic substrate competitors include an active phenolic unit. A process for treating a human or non-human subject includes administering to a subject a therapeutically effective amount of a salicylate and a salicylate pharmacokinetics modifier of glycine salicylate conjugate, gluconoride salicylate conjugate, benzoate, an aromatic derivative and an active phenolic unit, along with a pharmaceutically acceptable carrier.
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申请公布号 |
US2006293218(A1) |
申请公布日期 |
2006.12.28 |
申请号 |
US20060333008 |
申请日期 |
2006.01.17 |
申请人 |
MEYTHALER JAY M;NELSON JEAN P;MILLER LANDON C |
发明人 |
MEYTHALER JAY M.;NELSON JEAN P.;MILLER LANDON C. |
分类号 |
A61K38/04;A61F13/02;A61K31/192;A61K31/60;A61K31/7024;A61K31/717 |
主分类号 |
A61K38/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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