MODULATORS OF SPERM HYPERMOTILITY AND USES THEREOF

摘要

The invention provides novel compositions and compounds that inhibit CatSper channel activity, that preferentially inhibits sperm hyperactivity over sper m motility, or both. The compounds of the invention are useful as contraceptiv e agents that may be adminstered to males, females, or concurrently to both sexual partners. The invention further provides methods of conducting drug discovery business and of conducting a reproductive medicine business. The invention also provides methods of identifying compounds that modulate sperm hypermotility.