发明名称 |
HIGHLY POROUS POLYMERIC MATERIALS COMPRISING BIOLOGICALLY ACTIVE MOLECULES VIA COVALENT GRAFTING |
摘要 |
The present invention relates to highly porous polymeric materials comprising covalently grafted biologically active species. The invention also relates to a process for the preparation of highly porous materials comprising functional monomers capable of grafting to a biologically active molecular species comprising the steps of: (a) preparing an emulsion composition comprising a droplet phase and a continuous phase and containing monomers, (b) curing the emulsion and (c) optionally removing the water/droplet phase. The invention further relates to a process for grafting biologically active species to such a highly porous polymeric material comprising the steps of: (i) exposing the highly porous material to a solution of the biologically active species in a suitable solvent medium, (ii) optionally adding an activating agent, (iii) optionally heating, and (iv) rinsing the porous material with solvent medium to remove non-grafted species. The highly porous polymeric materials comprising covalently grafted biologically active species can be used e.g. as a heterogeneous catalyst, in biosensors, for chromatography, in biomedical devices and in implants.
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申请公布号 |
WO2006111399(A8) |
申请公布日期 |
2006.12.28 |
申请号 |
WO2006EP03677 |
申请日期 |
2006.04.21 |
申请人 |
DSM IP ASSETS B.V.;THIES, JENS CHRISTOPH;PIERRE, SEBASTIEN;CAMERON, NEIL RONALD;VAN HEST, JAN CORNELIS MARIA;WYMAN, PAUL |
发明人 |
THIES, JENS CHRISTOPH;PIERRE, SEBASTIEN;CAMERON, NEIL RONALD;VAN HEST, JAN CORNELIS MARIA;WYMAN, PAUL |
分类号 |
C12N11/06;A61K47/48;C08F2/32;C12N11/08 |
主分类号 |
C12N11/06 |
代理机构 |
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