VASCULAR TARGETING OF OCULAR NEOVASCULARIZATION

摘要

Methods of treating or preventing eye disease in a subject, involving administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a polypeptide having a vascular endothelial targeting amino acid sequence and a cytotoxic amino acid sequence are disclosed. For example, the vascular endothelial targeting amino acid sequence may be a VEGF sequence, such as a VEGF₁₂₁ sequence. Exemplary cytotoxic amino acid sequences include toxin sequences, such as gelonin, pro-apoptotic sequences, and anti-angiogenic sequences. The eye disease may be any eye disease, such as an eye disease associated with choroidal neovascularization, retinal neovascularization, iris neovascularization, or corneal neovascularization.