摘要 |
A pharmaceutical composition comprising an alpha-arylmethoxyacrylate derivative is provided to be able to excellently inhibit osteoclast formation and absorption activity thereof, thereby being effectively utilized for preventing metabolic bone diseases such as osteoporosis and ossification at a growth period. The pharmaceutical composition for preventing and treating metabolic bone disease comprises an alpha-arylmethoxyacrylate derivative represented by the formula(1), a physiologically acceptable salt thereof or a solvate thereof as an effective ingredient. In the formula(1), A is N or CH, X is H or halogen, Y is H, halogen or CF3, Z is substituted or unsubstituted N-containing heteroaryl or (CH2)n-NR^1R^2(where n is 0, 1 or 2 and each R^1 and R^2 is independently H, C1-8 alkyl, C1-8 haloalkyl, hydroxy, C2-8 alkenyl, C2-4 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkyl C1-4 alkyl, C1-4 alkoxy C1-4 alkyl, C3-8 cycloalkoxy C1-4 alkyl, C1-8 alkylsulfonyl, C2-7 heterocyclyl C1-4 alkyl containing at least one N, O or S, or substituted or unsubstituted aryl, or forms a heterocycle with adjacent N).
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申请人 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;OSCOTEC INC. |
发明人 |
KIM, BUM TAE;MIN, YONG KI;LEE, YEON SOO;HEO, JUNG NYOUNG;LEE, HYUK;PARK, NO KYUN;KIM, JUNG KEUN;KIM, SE WON;KO, SEON YLE |