THERAPEUTIC PRO-APOPTOTIC BH3-LIKE MOLECULES AND METHODS FORGENERATING AND/OR SELECTING THE SAME

摘要

The present invention relates generally to therapeutic molecules which are useful for modulating apoptosis in a target cell or cell population. More particularly, the present invention provides therapeutic agents which inhibi t pro-survival molecules and which are capable of inducing or facilitates apoptosis of a target cell or cell population such as cancer cells. The present invention further provides methods for generating or selecting the therapeutic molecules and pharmaceutical compositions comprising the therapeutic molecules.