1- ( 2-AMINO-3- (SUBSTITUTED ALKYL)-3H-BENZIMIDAZOIYLMETHYL) -3-SUBTITUTED-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONES WITH ACTIVITY ON RESPIRATORY SYNCYTIAL VIRUS

摘要

Inhibitors of RSV replication of formula (I) which can be represented by formula (I) the salts and stereochemically isomeric forms thereof, wherein R is a radical of formula (a) or (b); Q is hydrogen or C<SUB>1-6</SUB>alkyl optionally substituted with a heterocycle or Q is C<SUB>1-6</SUB>alkyl substituted with both a radical -OR<SUP>4</SUP> and a heterocycle; Alk is C<SUB>1-6</SUB>alkanediyl; X is O or S; -a<SUP>1</SUP>=a<SUP>2</SUP>-a<SUP>3</SUP>=a<SUP>4</SUP> - is -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH- or -CH=CH-CH=N-; R<SUP>1</SUP> is Ar or a heterocycle; R<SUP>2</SUP> is hydrogen, C<SUB>1-6</SUB>alkyl, substituted C<SUB>1-6</SUB>alkyl, C<SUB>3-7</SUB>cycloalkyl; R<SUP>3</SUP> is hydrogen, C<SUB>1-6</SUB>alkyl, cyano, aminocarbonyl, polyhaloC<SUB>1-6</SUB>alkyl, C<SUB>2-6</SUB>alkenyl or C<SUB>2-6</SUB>alkynyl; R<SUP>4</SUP> is hydrogen or C<SUB>1-6</SUB>alkyl; Ar is phenyl or substituted phenyl; Het is a heterocycle; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I).