摘要 |
FIELD: organic chemistry, medicine. ^ SUBSTANCE: invention relates to novel salts in order of 9-substituted 2-halogenphenylimidazo[1,2-a]benzimidazoles of the general formula (I): wherein R means (C1-C6)-alkyl, allyl, benzyl and substituted benzyl-, dialkylamino-alkyl; X means fluorine (F), chlorine (Cl), bromine (Br) atoms in ortho-, meta- and para-positions of phenyl ring, dihalides in 3,4-, 2,4-, 3,5- and in other position of phenyl ring; Y means Cl, Br, -NO3, -SO4, -(COOH)2, -(CH2COOH)2, -CH3-C6H4-SO3H and other pharmaceutically acceptable acid residues; n = 0-2 (with exception for compounds wherein R means -(CH2)2-NEt2; X means Br or Cl; Y means Cl; n = 2; R means -(CH2)2-NMe2; X = Y mean Cl; n = 2), and to intermediate compounds of their synthesis, namely to 1-substituted 3-halogenphenacyl-2-aminobenzimidazolium halides of the general formula (II): , wherein R means (C1-C6)-alkyl, allyl, benzyl and substituted benzyl-, dialkylamino-alkyl; X means F, Cl, Br at ortho-, meta- and para-positions of phenyl ring, dihalides at 3,4-, 2,4-, 3,5- and at other positions of phenyl ring; Y means Cl, Br, J (with exception for compounds wherein R means -(CH)2-NEt2; X means Br or Cl; Y means Br; R means -(CH2)2-NMe2; X means Cl; Y means Br) possessing hemorheological properties. Invention provides synthesis of novel biologically active compounds possessing hemorheological properties. ^ EFFECT: valuable medicinal properties of compounds. ^ 2 cl, 3 tbl, 31 ex |