发明名称 |
Cytotoxic agents containing novel potent taxanes and their therapeutic use |
摘要 |
Included within the scope of the present invention are potent taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient is also included. A method for inducing cell death in selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent is included as well. |
申请公布号 |
ZA200501129(B) |
申请公布日期 |
2006.12.27 |
申请号 |
ZA20050001129 |
申请日期 |
2005.02.08 |
申请人 |
IMMUNOGEN, INC. |
发明人 |
BALOGLU, ERKAN;MILLER, MICHAEL;CHARI, RAVI, V. J. |
分类号 |
A61K31/337;A61P31/04;A61P31/12;A61P33/00;A61P35/00;A61P37/06;A61P43/00;C07D;C07D305/14;C07D407/12;C07D407/14;C07D409/12 |
主分类号 |
A61K31/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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