RECOMBINANT FUSED PROTEIN, PREPARATION FOR IMMUNOTHERAPY BASED ON THEREOF AND METHOD FOR IMMUNOTHERAPY OF RELAPSING LARYNX PAPILLOMATOSIS

摘要

FIELD: medicine, biotechnology. ^ SUBSTANCE: invention relates to the development of a recombinant fused protein consisting of an oncoprotein E7 VPCH 11 type with a sequence SEQ 2 and protein of "heat shock" Hsp 70 from M. tuberculosis cells prepared by using plasmid pQE30-E711-dnaK in E. coli cells. The preparation is used against relapsing human papillovirus comprises the recombinant fused protein in the effective amount and a pharmaceutically acceptable carrier. Method for immunotherapy of relapsing larynx papillomatosis involves intracutaneous administration of indicated preparation in a patient. The advantage of invention involves the development of a novel preparation showing improved immunological indices. Proposed preparative formulations can be used in immunotherapy of relapsing larynx papillomatosis in humans. ^ EFFECT: valuable medicinal properties of protein, improved method for treatment. ^ 3 cl, 6 dwg, 7 ex