| 摘要 |
<p>Compounds (A) comprising a lipophilic component and a functional group bound to each other through a linker or a spacer are new. The linker is an amine group or a molecule with at least two functional groups and is bound to the lipophilic component. The functional group is a phosphonate- or a phosphoramidite group. The functional group is bound to the spacer through an oxygen atom. The spacer contains at least one carbon atom. Independent claims are also included for the following: (1) a compound (B) comprising a lipophilic component and a functional group connected to each other through a linker and a spacer, and a nucleoside, an oligonucleotide or polynucleotide; (2) preparation of modified nucleotides, oligonucleotides or polynucleotides; (3) identifying nucleic acids; (4) detecting the presence or absence of nucleic acids using specific sequences in a sample; (5) isolation of nucleic acid from a nucleic acid-containing sample; (6) kit for detecting compounds (B); (7) use of (B) for preparing nucleic acid arrays; and (8) device for nucleic acid analysis.</p> |
