| 发明名称 |
Substituted pyrazoles as p38 kinase inhibitors |
| 摘要 |
A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3 </SUP>and R<SUP>4 </SUP>are as described in the specification.
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| 申请公布号 |
US7153959(B2) |
申请公布日期 |
2006.12.26 |
| 申请号 |
US20030374781 |
申请日期 |
2003.02.25 |
| 申请人 |
PHARMACIA CORPORATION |
发明人 |
NARAIAN ASHOK S.;CLARE MICHAEL;COLLINS PAUL W.;CRICH JOYCE ZUOWU;DEVRAJ RAJESH;FLYNN DANIEL L.;GENG LIFENG;GRANETO MATTHEW J.;HANAU CATHLEEN E.;HANSON GUNNAR J.;HARTMANN SUSAN J.;HEPPERLE MICHAEL;HUANG HE;KOSZYK FRANCIS J.;LIAO SHUYUAN;METZ SUZANNE;PARTIS RICHARD A.;PERRY THAO D.;RAO SHASHIDHAR N.;SELNESS SHAUN RAJ;SOUTH MICHAEL S.;STEALEY MICHAEL A.;TALLEY JOHN JEFFREY;VAZQUEZ MICHAEL L.;WEIER RICHARD M.;XU XIANGDONG;KHANNA ISH K.;YU YI;NAING WIN;YANG SYAULAN |
| 分类号 |
C07D401/04;A61K31/415;A61K31/44;A61K31/4439;A61K31/445;A61K31/454;A61K31/47;A61K31/496;A61K31/50;A61K31/505;A61K31/506;A61K31/52;A61K31/5377;A61P1/04;A61P9/00;A61P11/00;A61P11/06;A61P13/12;A61P19/00;A61P19/02;A61P19/06;A61P29/00;A61P29/02;A61P43/00;C07D401/14;C07D403/04;C07D403/14;C07D405/14;C07D409/14;C07D413/02;C07D413/14;C07D417/14;C07D453/02;C07D471/04;C07D473/00;C07D487/04 |
主分类号 |
C07D401/04 |
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