Tamoxifen and 4-hydroxytamoxifen-activated system for regulated production of proteins in eukaryotic cells

摘要

Novel tamoxifen inducible and ICI 182,780 repressible expression systems comprising mutant estrogen receptors and mutant estrogen response element are disclosed. Such systems have a wide variety of applications, including gene therapy and in vivo and in vitro expression, as well as their use in transgenic animals.