| 摘要 |
A method of treatment of a disease of the human or animal body mediated by PARP comprising administering to such a subject a therapeutically effective amount of a compound of formula: or an isomer, salt, solvate, chemically protected form, and prodrug thereof, wherein: A and B together represent an optionally substituted, fused aromatic ring; R<SUB>C </SUB>is represented by -L-R<SUB>L</SUB>, where L is of formula: <?in-line-formulae description="In-line Formulae" end="lead"?>-(CH<SUB>2</SUB>)<SUB>n1</SUB>-Q<SUB>n2</SUB>-(CH<SUB>2</SUB>)<SUB>n3</SUB>-<?in-line-formulae description="In-line Formulae" end="tail"?> wherein n<SUB>1</SUB>, n<SUB>2 </SUB>and n<SUB>3 </SUB>are each selected from 0, 1, 2 and 3, the sum of n<SUB>1</SUB>, n<SUB>2 </SUB>and n<SUB>3 </SUB>is 1, 2 or 3 and Q is selected from O, S, NH, C(-O) or -CR<SUB>1</SUB>R<SUB>2</SUB>-, where R<SUB>1 </SUB>and R<SUB>2 </SUB>are independently selected from hydrogen, halogen or optionally substituted C<SUB>1-7 </SUB>alkyl, or may together with the carbon atom to which they are attached form a C<SUB>3-7 </SUB>cyclic alkyl group, which may be saturated (a C<SUB>3-7 </SUB>cycloalkyl group) or unsaturated (a C<SUB>3-7 </SUB>cycloalkenyl group), or one of R<SUB>1 </SUB>and R<SUB>2 </SUB>may be attached to an atom in R<SUB>L </SUB>to form an unsaturated C<SUB>3-7 </SUB>cycloalkenyl group which comprises the carbon atoms to which R<SUB>1 </SUB>and R<SUB>2 </SUB>are attached in Q, -(CH<SUB>2</SUB>)<SUB>n3</SUB>- (if present) and part of R<SUB>L</SUB>; and R<SUB>L </SUB>is optionally substituted C<SUB>5-20 </SUB>aryl; and R<SUB>N </SUB>is selected from hydrogen, optionally substituted C<SUB>1-7 </SUB>alkyl, C<SUB>3-20 </SUB>heterocyclyl, and C<SUB>5-20 </SUB>aryl, hydroxy, ether, nitro, amino, amido, thiol, thioether, sulfoxide and sulfone.
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