发明名称 NOVEL HETEROCYCLYL-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS
摘要 Compounds of formula (I) in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cydoalkoxy, 3-7C-cydoalkylmethoxy, 2,2- difluoroethoxy, or completely or predominantly fluorine-substituted 1-4C- alkoxy, R2 is hydroxyl, 1-4C-aikoxy, 3-7C-cydoalkoxy, 3-7C- cydoalkylmethoxy, 2,2-difluoroethoxy, or completely or predominantly fluorine-substituted 1-4C-alkoxy, or in which R1 and R2 together are a 1- 2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, either, in a first embodiment (embodiment a) according to the present invention, R4 is -O-R41, in which R41 is hydrogen, 1-4C-aikyl,1- 4C-alkoxy-1-4C-alkyl, hydroxy-2-C-alkyl, 1-7C-alkylcarbonyl, or completely or predominantly fluorine-substituted 1-4C-alkyl, and R5 is hydrogen or 1-4C-alkyl, or, in a second embodiment (embodiment b) according to the present invention, R4 Is hydrogen or 1-4C-alkyl, and R5 is -O-R51, in which R51 Is hydrogen, 1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, hydroxy-2-4C-alkyl. 1-7C-alkylcarbonyl, or completely or predominantly fluorine-substituted 1-4C-alkyl, R6 is hydrogen, halogen, 1-4C-alkyl or 1. 4C-alkoxy, R7 is Het1, Het2, Hart, Het3 or Har2, In which.
申请公布号 KR20060130684(A) 申请公布日期 2006.12.19
申请号 KR20067019918 申请日期 2006.09.26
申请人 ALTANA PHARMA AG 发明人 KAUTZ ULRICH;SCHMIDT BEATE;FLOCKERZI DIETER;HATZELMANN ARMIN;ZITT CHRISTOF;BARSIG JOHANNES;MARX DEGENHARD;KLEY HANS PETER
分类号 C07D221/12;C07D221/06;C07D401/10;C07D413/10;C07D417/10 主分类号 C07D221/12
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