发明名称 |
COMPOSITIONS AND METHODS FOR ENHANCING DELIVERY OF NUCLEIC ACIDS INTO CELLS AND FOR MODIFYING EXPRESSION OF TARGET GENES IN CELLS. |
摘要 |
<p>Polynucleotide delivery-enhancing polypeptides are admixed or complexed with, or conjugated to, nucleic acids for enhancing delivery the nucleic acids into cells. The transported nucleic acids are active in target cells as small inhibitory nucleic acids (siNAs) that modulate expression of target genes, mediated at least in part by RNA interference (RNAi). The siNA/polypeptide compositions and methods of the invention provide effective tools to modulate gene expression and alter phenotype in mammalian cells, including by altering phenotype in a manner that eliminates disease symptoms or alters disease potential in targeted cells or subject individuals to which the siNA/polypeptide compositions are administered.</p> |
申请公布号 |
MXPA06012605(A) |
申请公布日期 |
2006.12.15 |
申请号 |
MX2006PA12605 |
申请日期 |
2005.05.04 |
申请人 |
NASTECH PHARMACEUTICAL COMPANY INC. |
发明人 |
KUNYUAN CUI;LISHAN CHEN;YUCHING CHEN;SASHA J. MAYER |
分类号 |
A61K48/00;C12N15/11;C12N15/113 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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