BIOSENSOR AND IMMOBILIZATION METHOD OF PHYSIOLOGICALLY ACTIVE SUBSTANCE

摘要

PROBLEM TO BE SOLVED: To provide a biosensor that can obtain a pre-concentration effect at pH 3.5 or less which is acid dissociation constant of carboxyl group and can covalently bind a physiologically active substance to a surface, and to provide an immobilization method of the physiologically active substance. SOLUTION: The biosensor has a surface having a reactive group capable of chemically immobilizing the physiologically active substance and anion group having an acid dissociation constant lower than the acid dissociation constant of carboxyl group. COPYRIGHT: (C)2007,JPO&INPIT