ANTI AMYLOID-RELATED DISEASE MOLECULES AND THEIR USES

摘要

Oligonucleotides formulation comprising oligonucleotides having an anti amyloid-related disease activity that act by a sequence independent mechanism. The anti amyloid-related disease activity is greater for large oligonucleotides and for oligonucleotides with sulfur modification. The invention also relates to oligonucleotides and their use as therapeutic agents, and more particularly for their use and formulations for the treatment of amyloid-related diseases. The modified oligonucleotides are included in the present invention, for example, ONs containing modified backbones.