PROCESS TO OBTAIN DIBENZYLBUTYROLACTONIC, TETRAHYDROFURANIC LIGNANS AND THEIR SYNTHETIC AND SEMI-SYNTHETIC DERIVATIVES, THEIR ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES, TOPICAL AND/OR SYSTEMIC FORMULATIONS CONTAINING SAID LIGNANS AND THEIR RESPECTIV

摘要

The present invention refers to a process to obtain dibenzylbutyrolactonic lignans form (-)- cubebin, insolate from a Piperaceae, especially Piper cubeba, and from (-)-methylpluviatolide insolated form a Rutacea, especially Zanthoxylum naranjillo; their synthetic and semisyntheti derivatives and tetrahydrofuranic lignans, such as glagravin and veragensin, insolated form Nectandra meapotamica, as well as the analgesic and anti-inflammatory activities of said lignans, and the topical and/or systemic formulatins where lignans present 60 to 80% of the formulation. The invention also refers to a therapeutic method using topic and/or systemic formulations based on said lignans for the treatment of inflammation and/or pain. More specifically, it refers to a process to obtain synthetic and semi-synthetic derivatives of (-)- cubebin such as: - -O-acet l cubebin; - -O-meth l cubebin - -O- N N-dimeth lamino-ethyl)- cubebin; (-)-hinokinin; (-)6,6'-dinitroinokinin; (-)-o-benzyl cubebin; (-)-6,6'-diaminohinokinin and other synthetic derivatives which may be obtained, and synthetic and semi-synthetic derivatives of (-)-methylpluviatolide, such as (-)-6,6'-dinitromethylpluviatolide and (-)6,6'- diaminomethylpluviatolide, to be used in the manufacture of medicine that has analgesic and anti-inflammatory activity. The present invention also refers to the process ot obtain the substances glagravin and veragensin islated from Nectandra megapotamica, as well as their synthetic and semi-synthetic derivatives with substituents on the aromatic rings that may be obtained.