Resolution of enantiomeric mixtures of beta-lactams

摘要

A new process for resolution of an enantiomeric mixture of C3-hydroxyl substituted beta-lactams is disclosed. Generally, the enantiomeric mixture is treated with an optically active proline acylating agent to form a C3-ester substituted beta-lactam diastereomer or a mixture of C3-ester substituted beta-lactam diastereomers followed by selective recovery of the unreacted enantiomer or of one of the diastereomers.