发明名称 |
OLIGORIBONUCLEOTIDES AND METHODS OF USE THEREOF FOR TREATMENT OF FIBROTIC CONDITIONS AND OTHER DISEASES |
摘要 |
<p>The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a gene of the TGase family at post-transcriptional level. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from fibrotic disease such as kidney and liver fibrosis and ocular scarring comprising administering to the patient the pharmaceutical composition in a therapeutically effective amount so as to thereby treat the patient. The invention also relates to treatment of fibrotic and other diseases by use of antibodies to TGase polypeptides.</p> |
申请公布号 |
WO2006131925(A2) |
申请公布日期 |
2006.12.14 |
申请号 |
WO2006IL00671 |
申请日期 |
2006.06.08 |
申请人 |
QUARK BIOTECH INC;MOR, ORNA;FEINSTEIN, ELENA |
发明人 |
MOR, ORNA;FEINSTEIN, ELENA |
分类号 |
A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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