INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND 5'METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE
摘要
Described are compounds of the general formula (I), VI and (VII). Also described are pharmaceutical compositions comprising the compounds identified. The compounds and pharmaceutical compositions described are inhibitors of 5'-methylthioadenosine/S-adenosylhomocystein nucleosidase (MTAN) and/or 5'-methylthioadenosine phosphorylase (MTAP). Methods of treatment using the compounds and pharmaceutical compositions described are also provided for preventing and/or treating disease states and/or conditions by inhibiting MTAN and/or MTAP in patients.
申请公布号
WO2006014913(A3)
申请公布日期
2006.12.14
申请号
WO2005US26419
申请日期
2005.07.26
申请人
BIOCRYST PHARMACEUTICALS, INC.;BABU, YARLAGADDA S.;KAMATH, VIVEKANAND P.;MORRIS, JR., PHILIP E.
发明人
BABU, YARLAGADDA S.;KAMATH, VIVEKANAND P.;MORRIS, JR., PHILIP E.