Process for preparing renin inhibitors

摘要

The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula III,
wherein R, R 1 , R 2 , R 3 and PG are as defined in the specification, or a salt thereof, said manufacture comprising (preferably consisting in)
reacting a compound of the formula I,
with a reagent able to transform hydroxy into X where X is for example a leaving group.