METHODS FOR PURIFYING TRANS-(-)-?9-TETRAHYDROCANNABINOL AND TRANS-(+)-?9-TETRAHYDROCANNABINOL

摘要

Methods for making trans-(-)-?⁹-tetrahydrocannabinoI and trans-(+)-?⁹-tetrahydrocannabinol are disclosed herein. In one embodiment, a trans-(-)-?⁹-tetrahydrocannabinoI composition is prepared by allowing a composition comprising (±)-?⁹-tetrahydrocannabinol to separate on a chiral stationary phase to provide a trans-(-)-?⁹-tetrahydrocannabinoI composition comprising at least about 99% by weight of trans-(-)-?⁹-tetrahydrocannabinol based on the total amount of trans-(-)-?⁹-tetrahydrocannabinol and trans-(+)-?⁹-tetrahydrocannabinol. The invention also relates to methods for treating or preventing a condition such as pain comprising administering to a patient in need thereof an effective amount of a trans-(-)-?⁹-tetrahydrocannabinoI having a purity of at least about 98% based on the total weight of cannabinoids.