CYCLOHEXANESULFONYL DERIVATIVES AS GLYT1 INHIBITORS TO TREAT SCHIZOPHRENIA

摘要

The present invention provides compounds of formula (I): wherein R<SUP>1</SUP> is an alkyl, phenyl, heterocyclyl, cycloalkyl, alkoxy, ester, amino or amide group; R<SUP>2</SUP> is a phenyl, heterocyclyl, alkyl, cycloalkyl or cycloalkylalkyl group; R<SUP>3</SUP> is an alkyl, cycloalkyl, cycloalkylalkyl, amino or heterocyclyl group; R<SUP>4</SUP> and R<SUP>5</SUP> are hydrogen or alkyl or form a cycloalkyl ring; A is O or N; and m is zero or one; as inhibitors of GlyT1 and thus as useful for treating or preventing diseases such as schizophrenia; with the provision of pharmaceutical compositions, first and second medical uses and methods of treatment.