TREATMENT OF TNF ANTAGONIST-RESISTANT INFLAMMATORY DISORDERS AND RELATED METHODS
摘要
In certain embodiments, the invention provides methods of treatment in which a VLA-I antagonist is administered to a patient who suffers from one or more inflammatory disorders, wherein: (1) the patient does not respond adequately to, or is unlikely to respond adequately to, TNFa antagonist therapy; or (2) the patient evidences tachyphylaxis and/or refractory effects during TNFa antagonist therapy; or (3) the VLA-I antagonist is administered as an adjuvant to TNFa antagonist monotherapy; and (4) wherein administration of the VLA-I antagonist is effective in treating the patient's inflammatory disorder(s).
申请公布号
WO2006133286(A2)
申请公布日期
2006.12.14
申请号
WO2006US22099
申请日期
2006.06.07
申请人
TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.;BANK, ILAN;GOLDSTEIN, ITAMAR;BEN HORIN, SHOMRON;CHESS, LEONARD;ALEXANDER, KOLTAKOV
发明人
BANK, ILAN;GOLDSTEIN, ITAMAR;BEN HORIN, SHOMRON;CHESS, LEONARD;ALEXANDER, KOLTAKOV