| 发明名称 |
METHOD OF PRODUCING ANTIBODIES WITH MODIFIED FUCOSYLATION LEVEL |
| 摘要 |
The invention provides methods for controlling fucosylation levels and improving ADCC activity in antibodies, by inhibiding the expression of FUT8 in antibody-producing cells.
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| 申请公布号 |
CA2608818(A1) |
申请公布日期 |
2006.12.14 |
| 申请号 |
CA20062608818 |
申请日期 |
2006.06.05 |
| 申请人 |
GENENTECH, INC. |
发明人 |
LOWMAN, HENRY B.;JOLY, JOHN C.;SNEDECOR, BRADLEY R.;SHEN, AMY Y.;NG, DOMINGOS |
| 分类号 |
C07K16/00;A61K39/395;C07K16/28;C12N9/10;C12N15/113;C12N15/13 |
主分类号 |
C07K16/00 |
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