| 发明名称 |
METHOD OF ENGINEERING A CYTIDINE MONOPHOSPHATE-SIALIC ACID SYNTHETIC PATHWAY IN FUNGI AND YEAST |
| 摘要 |
The present invention provides methods for generating CMP-sialic acid in a non-human host which lacks endogenous CMP-Sialic by providing the host with enzymes involved in CMP-sialic acid synthesis from a bacterial, mammalian or hybrid CMP-sialic acid biosynthetic pathway. Novel fungal hosts expressing a CMP-sialic acid biosynthetic pathway for the production of sialylated glycoproteins are also provided. |
| 申请公布号 |
EP1730293(A2) |
申请公布日期 |
2006.12.13 |
| 申请号 |
EP20050732104 |
申请日期 |
2005.03.17 |
| 申请人 |
GLYCOFI, INC. |
发明人 |
HAMILTON, STEPHEN, R. |
| 分类号 |
C12P21/00;C12N1/14;C12N1/18;C12N5/10;C12N9/10;C12N9/12;C12N9/16;C12N9/88;C12N9/90;C12N15/52;C12N15/81;C12P19/26;C12R1/645 |
主分类号 |
C12P21/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
