SOLID PHARMACEUTICAL PREPARATION CONTAINING SPARINGLY WATER-SOLUBLE DRUG

摘要

Even when being released in a region from a lower small intestine to a large intestine with various coatings, bisacodyl is inadequately effective because of its hardness to dissolve due to its poor solubility, and thus a more drug should be contained. In the related art, there have been no techniques for allowing bisacodyl and dioctyl sodium sulfosuccinate to be simultaneously released in a region from a lower small intestine to a large intestine. A solid formulation having a core particle containing bisacodyl and dioctyl sodium sulfosuccinate coated with an enteric coating which allows the drugs to be released in a region from a lower small intestine to a large intestine can be used as an excellent pharmaceutical product.