| 发明名称 |
IMPROVED INTERLEUKIN-2 MUTEINS |
| 摘要 |
<p>Methods for predicting patient tolerability to therapeutic agents, such as cytokines, lymphokines and immunotoxins, are disclosed. The methods utilize an in vitro model of vascular leak syndrome (VLS) to assess the effect of the agent in question on the permeability of large proteins across confluent monolayers of endothelial cells (EC).</p> |
| 申请公布号 |
EP1730184(A2) |
申请公布日期 |
2006.12.13 |
| 申请号 |
EP20050731874 |
申请日期 |
2005.03.04 |
| 申请人 |
CHIRON CORPORATION |
发明人 |
DENIS-MIZE, KIMBERLY;HEISE, CARLA;MENEZES, DANIEL;WILSON, SUSAN, E. |
| 分类号 |
C12N15/09;A61K38/00;C07K14/435;C07K14/55;C07K14/705;C12N15/10;C12N15/19;C12N15/26;C12P21/02;C12Q1/00;C12Q1/02;G01N33/50;G01N33/68 |
主分类号 |
C12N15/09 |
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