发明名称 |
INCLUSION COMPLEXES CONTAINING PIROXICAM, A CYCLODEXTRIN AND ARGININE |
摘要 |
<p>Soluble inclusion complex comprising one or several active substances difficult to dissolve in aqueous medium including one or several host molecules and piroxicam-cyclodextrin-arginine in which the level of solubilization of piroxicam in solution containing 4 g/liter piroxicam in water, measured at 37[deg]C with agitation over 5-120 minutes is higher than 90%, most especially higher than 99%. INDEPENDENT CLAIM are included for: (1) preparation of the complex involving:contact with host molecules, initation of molecular diffusion, recovery of the soluble inclusion compound formed; (2) a pharmaceutical composition containing the complex.</p> |
申请公布号 |
EP1729813(A2) |
申请公布日期 |
2006.12.13 |
申请号 |
EP20050744579 |
申请日期 |
2005.03.29 |
申请人 |
PIERRE FABRE MEDICAMENT |
发明人 |
FREISS, BERNARD;MARCIACQ, FLORENCE;LOCHARD, HUBERT |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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