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摘要

A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein: R¹, R², R³ and R²⁰ are each independently H, CI, Br, F, I, CF₃, OCF₃, Me or Et; R⁴ is het or C_3-7 cycloalkyl optionally substituted by C_1-4 alkyl, C_1-4 alkoxy, alkoxyalkyl containing 2 to 4 carbon atoms or -S-(C_1-4 alkyl); a is 0 or 1; and het is a non-aromatic 4-, 5- or 6- membered heterocycle which contains at least one N, O or S heteroatom, optionally fused to a 5- or 6- membered carbocyclic group or a second 4-, 5- or 6-membered heterocycle which contains at least one N, O or S heteroatom, wherein the het group is optionally substituted by at least one substituent independently selected from C_1-8alkyl, C_1-8alkoxy, OH, halo, CF₃, OCF₃, SCF₃, hydroxy-C_1-6alkyl, C_1-4 alkoxy-C_1-6alkyl and C_1-4 alkyl-S-C_1-4alkyl; provided that at least one of R¹, R² and R³ are other than H. The compounds of the invention exhibit activity as both serotonin and noradrenaline re-uptake inhibitors and therefore have utility in a variety of therapeutic areas, for example urinary incontinence.