发明名称 |
Synthesis and screening of ligands using X-ray crystallography |
摘要 |
A method for identifying a ligand of a target macromolecule is disclosed, comprising the steps of: soaking one or more crystals of the target macromolecule in a solution containing a collection of compounds generated in situ or separate from the crystal, where the solution has been prepared without the purification of the synthesized collection of compounds; obtaining an X-ray crystal diffraction pattern of the soaked macromolecule crystal; and using said X-ray crystal diffraction pattern to identify any compound bound to the macromolecule crystal, said compound being a ligand of the target macromolecule.
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申请公布号 |
US7149280(B2) |
申请公布日期 |
2006.12.12 |
申请号 |
US20050539447 |
申请日期 |
2005.08.30 |
申请人 |
ASTEX THERAPEUTICS LIMITED |
发明人 |
JHOTI HARREN;CONGREVE MILES STUART;O'REILLY MARC;WYATT PAUL GRAHAM |
分类号 |
G01N23/207;C40B30/04;G01N23/20;G01N33/53;G01N33/68 |
主分类号 |
G01N23/207 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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