| 摘要 |
Methods for agents useful for treating asthma are disclosed. The methods include screening for agents that inhibit the production of a PKC- theta protein, as well as for agents that inhibit the kinase activity of a PKC-theta protein, or a functional fragment thereof, wherein such agents are useful for treating asthma. The methods also include screening for agents that inhibit the production of a reporter gene product encoded by a nucleic acid sequence operably linked to a PKC-theta promoter. Also disclosed are methods of treating asthma that include administering an agent that inhibits the production of a functional PKC-theta protein or the kinase activity of a PKC-theta protein or a functional fragment thereof. An isolated mast cell lacking expression of endogenous PKC- theta is also disclosed.
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