发明名称 Antisense modulation of bcl-x expression
摘要 Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associated with expression of bcl-x are also provided. Methods of sensitizing cells to apoptotic stimuli are also provided.
申请公布号 US7148204(B2) 申请公布日期 2006.12.12
申请号 US20020302262 申请日期 2002.11.21
申请人 ISIS PHARMACEUTICALA, INC. 发明人 BENNETT C. FRANK;DEAN NICHOLAS M.;MONIA BRETT P.;NICKOLOFF BRIAN J.;ZHANG VIVIAN Q.
分类号 A61K31/70;C12N15/09;A01N43/04;A61K9/10;A61K31/337;A61K31/711;A61K31/7115;A61K31/712;A61K31/7125;A61K33/24;A61K38/00;A61K48/00;A61P35/00;A61P43/00;C07H21/04;C12N5/10;C12N15/113;C12R1/91 主分类号 A61K31/70
代理机构 代理人
主权项
地址