发明名称 |
GENETICALLY ENGINEERED VACCINE STRAIN |
摘要 |
What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encod ed genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivat ed by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to knwon recombinant virus vaccines.
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申请公布号 |
CA2105277(C) |
申请公布日期 |
2006.12.12 |
申请号 |
CA19922105277 |
申请日期 |
1992.03.09 |
申请人 |
VIROGENETICS CORPORATION |
发明人 |
COX, WILLIAM I.;FRANCIS, JEAN-CHRISTOPHE;GETTIG, RUSSELL R.;PAOLETTI, ENZO;PERKUS, MARION E.;TAYLOR, JILL;TARTAGLIA, JAMES;NORTON, ELIZABETH K.;RIVIERE, MICHEL;DE TAISNE, CHARLES;LIMBACH, KEITH J.;JOHNSON, GERARD P.;PINCUS, STEVEN E. |
分类号 |
A61K39/12;C12N15/86;A61K39/00;A61K39/08;A61K39/15;A61K39/165;A61K39/17;A61K39/205;A61K39/21;A61K39/23;A61K39/245;A61K39/275;A61K39/285;A61K39/29;A61P31/04;A61P31/12;A61P31/14;A61P31/16;A61P31/18;A61P31/20;A61P31/22;C07K14/015;C07K14/02;C07K14/03;C07K14/035;C07K14/045;C07K14/05;C07K14/06;C07K14/065;C07K14/07;C07K14/11;C07K14/12;C07K14/125;C07K14/145;C07K14/15;C07K14/155;C07K14/16;C07K14/175;C07K14/18;C07K14/33;C12N7/00;C12N7/01;C12N7/04;C12N7/08;C12N15/09;C12N15/863;C12R1/93 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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