| 摘要 |
The present invention relates to autoantigenic vaccine peptides comprising a universal helper T cell epitope portion linked to a B cell epitope portion from the N-terminus of cholesteryl ester transfer protein (CETP). The vaccine peptides are useful for eliciting an autoimmune response in a vaccinated individual, i.e., raising antibodies against the individual's endogenous CETP, in turn modulating circulating CETP activity, reducing LDL-cholesterol levels, and increasing HDL-cholesterol levels, which in turn is helpful to treat cardiovascular disease, such as atherosclerosis.
|
