A dry manufacturing process for the production of a pharmaceutical formulation of a benzimidazole and an alkaline substance is described. A tablet is compressed directly from a dry powder or a dry particulate matter avoiding any liquid or excipient conventionally used as a wet binder. The manufacturing process has the advantage of being simple and cost efficient. At the same time an expensive drying step is superfluous. The resulting pharmaceutical formulation has a good stability and a good dissolution profile.
申请公布号
WO2006105798(A3)
申请公布日期
2006.12.07
申请号
WO2006DK00409
申请日期
2006.07.11
申请人
NYCOMED DANMARK APS;BERTELSEN, POUL;OLSEN, PEDER, MOHR