发明名称 Cells and methods for estimation of effects on neurological dysfunction
摘要 The invention provides neuron-derived cells obtained by transfecting a receptor-expressing nucleic acid having an aryl hydrocarbon receptor gene, wherein outgrowth of neurites is not observed without adding a substance for the aryl hydrocarbon receptor, and outgrowth of neurites is observed by adding the substance for the aryl hydrocarbon receptor. The invention also provides a method for determining the presence of neurotoxicity of a test substance, a method for acquiring a marker for determining the presence of neurotoxicity of the test substance, a method for acquiring a marker for neurological dysfunction, and a method for determining the effect of the test substance on neurological dysfunction using such cells.
申请公布号 US2006275275(A1) 申请公布日期 2006.12.07
申请号 US20060442314 申请日期 2006.05.30
申请人 KABUSHIKI KAISHA TOSHIBA 发明人 YOSHIMURA SEIKO;AKAHOSHI EIICHI;ISHIHARA MITSUKO
分类号 A61K48/00;C12N5/08 主分类号 A61K48/00
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