发明名称 |
Endogenous retrovirus up-regulated in prostate cancer |
摘要 |
A specific member of the HERV-K family located in chromosome 22 at 20.428 megabases (22q11.2) has been found to be preferentially and significantly up-regulated in prostate tumors. The invention provides methods for diagnosing prostate cancer, comprising the step of detecting in a patient sample the presence or absence of an expression product of the virus. The virus has five features not seen in other HERV-K members: (1) its own specific nucleotide sequence, and consequently amino acid sequences; (2) tandem 5' LTRs; (3) a fragmented 3' LTR; (4) an env gene interrupted by an alu insertion; and (5) unique gag sequences.
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申请公布号 |
US2006275747(A1) |
申请公布日期 |
2006.12.07 |
申请号 |
US20050498033 |
申请日期 |
2005.12.22 |
申请人 |
HARDY STEPHEN F;GARCIA PABLO;WILLIAMS LEWIS T;ESCOBEDO JAIME |
发明人 |
HARDY STEPHEN F.;GARCIA PABLO;WILLIAMS LEWIS T.;ESCOBEDO JAIME |
分类号 |
C12Q1/70 |
主分类号 |
C12Q1/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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